This really struck a chord with me about Serial:
The real question at the heart of Serial, it turns out, was not “Who killed Hae Min Lee?” It was something more banal, more universal: How do we make decisions, particularly decisions about whom to trust? (Vox)
You can probably add “is it possible to really understand what makes a human being tick IF you spend enough time with them” to that (now) two-question list as well.